Inhibition of complement activation in cardiac surgery
نویسندگان
چکیده
منابع مشابه
Complement Activation and Inhibition in Wound Healing
Complement activation is needed to restore tissue injury; however, inappropriate activation of complement, as seen in chronic wounds can cause cell death and enhance inflammation, thus contributing to further injury and impaired wound healing. Therefore, attenuation of complement activation by specific inhibitors is considered as an innovative wound care strategy. Currently, the effects of seve...
متن کاملCAUSES OF MORTALITY IN CARDIAC SURGERY REOPERATIONS
From March 1990 to May 1993,309 patients underwent redo cardiac surgery operation at the Shahid Rajai Heart Hospital in Tehran. Early mortality rates in these patients showed a significant increase in comparison to patients undergoing open heart surgery for the first time. Late mortality (at least one month after surgery) in the patients was slightly increased also but less than early morta...
متن کاملNo prominent role for terminal complement activation in the early myocardial reperfusion phase following cardiac surgery.
OBJECTIVES Complement activation is considered an important mediator of myocardial ischaemia/reperfusion (I/R) injury. Although complement inhibitors are highly effective in animals, clinical trials fail to show a substantial benefit in humans. This raises questions on the role of complement activation in human myocardial I/R injury. METHODS Soluble C5b-9, i.e. terminal complement complex, an...
متن کاملBeneficial effects of complement inhibition with soluble complement receptor 1 (TP10) during cardiac surgery: is there a gender difference?
BACKGROUND TP10, a potent inhibitor of complement activation during cardiopulmonary bypass (CPB) has been shown to significantly reduce the incidence of death and myocardial infarction (MI) in high-risk male patients undergoing cardiac surgery. However, the effect of TP10 in females was undefined because of the limited number of females studied. To examine the possibility of a gender effect, th...
متن کاملAnesthesia Issues in Cardiac Surgery
The principle of anaesthesia for open-heart surgery is based on simplicity, safty and lightplane of anaesthesia. As a result of the special pathophysiology, grave general status, complications threatening these patients during and after the operation and the abundance of medicines available nowadays, it is very important for the anaesthetist to be acquainted with the pathophysiological and ph...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2006
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2005.10.019